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Significance The central nervous system’s rostral sector consists of forebrain and midbrain, and this sector is responsible for coordinating voluntary behavior, cognition, and affect with instinctive survival behaviors and bodily… Click to show full abstract
Significance The central nervous system’s rostral sector consists of forebrain and midbrain, and this sector is responsible for coordinating voluntary behavior, cognition, and affect with instinctive survival behaviors and bodily physiology. To clarify biological mechanisms underlying this coordination, we have generated a hierarchical structure–function subsystem model of intrarostral sector neuronal connectivity, and we have examined how localized changes in connectivity impact global network architecture. Three key factors are found to play a significant role: the hub score (centrality) of altered nodes, the hierarchy position of the altered nodes, and the distribution of altered node input and output connections within the subsystem network. This conceptual framework is a hypothesis-generating engine for clarifying mechanisms linking neuronal subsystems, behavior, and disease.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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