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Significance C-to-U RNA editing in plant organelles is carried out by a PPR-DYW protein or a protein complex that harnesses site recognition and deaminase activity. E-type PPR proteins can specify… Click to show full abstract
Significance C-to-U RNA editing in plant organelles is carried out by a PPR-DYW protein or a protein complex that harnesses site recognition and deaminase activity. E-type PPR proteins can specify the editing site but lack the deaminase activity. This study shows that E-type PPR proteins specifically recruit trans deaminase MEF8/MEF8S, while GRP23, MORF1, and MORF8 facilitate this recruitment. In addition, some PPR-DYW proteins also need GRP23, presumably to recruit a second deaminase. This study reveals the functions of GRP23, MEF8/MEF8S, MORF1, and MORF8 and furthers our understanding of the RNA-editing mechanism in plant organelles.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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