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Significance The study uses thousands of bacterial genome sequences to comprehensively dissect the evolutionary history of a leading bacterial pathogen of livestock. Remarkably, contemporary bovine mastitis infections due to Staphylococcus… Click to show full abstract
Significance The study uses thousands of bacterial genome sequences to comprehensively dissect the evolutionary history of a leading bacterial pathogen of livestock. Remarkably, contemporary bovine mastitis infections due to Staphylococcus aureus can be traced back to historic host switch events that originated in humans up to thousands of years ago. The host jumps were followed by host adaptation by acquisition of different gene combinations followed by global dissemination via established cattle trade links. Our work reveals high-risk clones that undergo more frequent cross-species transmission and which may therefore represent greater threat to public or animal health.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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