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Significance CRH is a well-known neuropeptide hormone associated with stress response and anxiety. It is mainly secreted by paraventricular neurons in the hypothalamus. However, CRH is also produced by a… Click to show full abstract
Significance CRH is a well-known neuropeptide hormone associated with stress response and anxiety. It is mainly secreted by paraventricular neurons in the hypothalamus. However, CRH is also produced by a sparse population of cortical interneurons that project locally in the medial prefrontal cortex. Using genetic manipulations, we show that CRH released by this interneuron population regulates exploration of novel objects and novel mice in a sex-specific manner.
Keywords:
hormone;
production corticotropin;
local production;
exploration;
prefrontal cortex
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!