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Significance Degeneration of retinal neurons underlies a variety of blinding eye diseases. Thus, restoring lost neurons is a major goal of vision scientists. One approach is to use endogenous stem… Click to show full abstract
Significance Degeneration of retinal neurons underlies a variety of blinding eye diseases. Thus, restoring lost neurons is a major goal of vision scientists. One approach is to use endogenous stem cells to regenerate damaged retinal neurons. Unlike mammals, zebrafish can regenerate a damaged retina. Key to this regenerative response are Müller glia (MG), a retinal cell type found in both fish and mammals. Understanding how MG attain stem cell properties in zebrafish may suggest strategies for stimulating a similar regenerative response by human MG. Here, we report that Vegf signaling is critical for imparting zebrafish MG with stem cell properties and that this signaling pathway links immune cells and vascular endothelial (VE) cells with MG reprogramming and proliferation.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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