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Significance Metabolic homeostasis plays a vital role in animal growth. Here, we show that acetylation of fatty acid synthase (FASN) contributes to de novolipogenesis during fly development. Although acetylation of… Click to show full abstract
Significance Metabolic homeostasis plays a vital role in animal growth. Here, we show that acetylation of fatty acid synthase (FASN) contributes to de novolipogenesis during fly development. Although acetylation of most proteins is catalyzed by various acetyltransferases (KATs), we unexpectedly find that acetylation of FASN at K813 residue does not require the participation of any known KATs, while it is directly regulated by abundance of acetyl-CoA via a conserved motif nearby K813. The ability to sense and respond to nutrient availability is essential for organisms to maintain metabolic homeostasis and sustain life. Our work highlights a novel metabolite sensing mechanism and a self-regulatory system in the control of metabolic homeostasis through acetyl-CoA-mediated autoacetylation.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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