Significance Multidrug-resistant Acinetobacter baumannii is a major public health threat, causing difficult-to-treat nosocomial infections. We identified two virulence pili independently critical to A. baumannii catheter-associated urinary tract infections, the chaperone-usher… Click to show full abstract
Significance Multidrug-resistant Acinetobacter baumannii is a major public health threat, causing difficult-to-treat nosocomial infections. We identified two virulence pili independently critical to A. baumannii catheter-associated urinary tract infections, the chaperone-usher pathway pili Abp1 and Abp2. Mechanistically, these pili contribute to A. baumannii biofilm formation. Further, their respective tip-adhesive proteins, the adhesins Abp1D and Abp2D, make use of large, distally oriented binding pockets to adhere to glycoproteins like fibrinogen, a wound-healing protein important in CAUTI pathogenesis.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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