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Significance This study assesses the role of embryonic microRNAs (miRNAs) in preimplantation embryo development using a bovine model, which is a more appropriate model to study the maternal-to-embryo transition during… Click to show full abstract
Significance This study assesses the role of embryonic microRNAs (miRNAs) in preimplantation embryo development using a bovine model, which is a more appropriate model to study the maternal-to-embryo transition during preimplantation development than the more commonly used rodent models. Using small RNA sequencing, a knockdown of embryonic miRNAs, and live embryo imaging, we demonstrate that embryonic miRNAs are essential for blastocyst development in bovine embryos. The results in this study are notably different from those observed in mouse and will likely be useful in future studies pursuing the role of specific miRNAs in preimplantation embryo development.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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