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Significance Exposure of mice to aspartame, an artificial sweetener found in nearly 5,000 diet foods and drinks, at doses equivalent to below 15% of the FDA recommended maximum daily intake… Click to show full abstract
Significance Exposure of mice to aspartame, an artificial sweetener found in nearly 5,000 diet foods and drinks, at doses equivalent to below 15% of the FDA recommended maximum daily intake for humans, produces anxiety-like behavior. The anxiety is alleviated by diazepam, a drug used in the treatment of generalized anxiety disorder. The aspartame exposure produces changes in the expression of genes regulating excitation-inhibition balance in the amygdala, a brain region that regulates anxiety and fear. The anxiety, its response to diazepam and the changes in amygdala gene expression are not limited to the aspartame-exposed individuals but also appear in up to two generations descending from the aspartame-exposed males.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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