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Significance The structure of NuA4, one of two major histone acetyltransferases of Saccharomyces cerevisiae, is reported at 3.8 Å resolution. Six polypeptide chains of the complex, comprising about half the… Click to show full abstract
Significance The structure of NuA4, one of two major histone acetyltransferases of Saccharomyces cerevisiae, is reported at 3.8 Å resolution. Six polypeptide chains of the complex, comprising about half the total mass, could be traced. This region is conserved from yeast to humans. Part of the complex performs a negative role, diminishing the affinity of the acetyltransferase for the nucleosome.
Keywords:
structure;
histone acetyltransferase;
nua4 histone;
acetyltransferase complex;
structure nua4
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!