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Significance Super-enhancers (SEs) are exceptionally large enhancers and play prominent roles in cell type identity and function in mammalian species. We identified a set of 749 putative SEs in the… Click to show full abstract
Significance Super-enhancers (SEs) are exceptionally large enhancers and play prominent roles in cell type identity and function in mammalian species. We identified a set of 749 putative SEs in the model plant Arabidopsis thaliana. We demonstrate that the SEs share the functional characteristics of mammalian SEs.We developed several small deletions within an SE located in the middle of the thalianol biosynthetic gene cluster. The deletion lines show distinct phenotypic changes and transcriptional repression of all five thalianol cluster genes. Our results suggest that SEs play important roles in regulating genes associated with development and tissue identity and in coordinating the coexpression of gene clusters in A. thaliana.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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