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Significance In a nationally representative US adult population, measures of epigenetic age acceleration are associated with concurrent cognitive dysfunction, functional limitations and chronic conditions measured 2 y after DNA methylation… Click to show full abstract
Significance In a nationally representative US adult population, measures of epigenetic age acceleration are associated with concurrent cognitive dysfunction, functional limitations and chronic conditions measured 2 y after DNA methylation measurement, and 4-y mortality. PC-based clocks do not significantly change the relationship between DNAm-based age acceleration and health outcomes. These findings suggest that along with demographic measures, SES, mental health, and health behaviors, epigenetic age acceleration serves as a useful tool to facilitate investigation into the biology of aging and helps in the prediction of later life morbidity and mortality.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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