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Significance This report documents for the first time the essential and selective relevance of DNA damage tolerance (DDT) in warranting the survival of HSPCs and mammalian life. DDT prevents the… Click to show full abstract
Significance This report documents for the first time the essential and selective relevance of DNA damage tolerance (DDT) in warranting the survival of HSPCs and mammalian life. DDT prevents the accumulation of DNA damage in HSPCs, which results in cell cycle defects and apoptosis. Defects in DDT promote the survival of cells expressing erythroid transcription factors KLF1. These insights indicate a novel molecular mechanism that regulates hematopoietic output in response to DNA damage.
Keywords:
dna damage;
damage tolerance;
mammalian life;
damage
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!