LAUSR

Significance SynthSeg+ is an image segmentation tool for automated analysis of highly heterogeneous brain MRI clinical scans. Our method relies on a new strategy to train deep neural networks, such that it can robustly analyze scans of any contrast and resolution without retraining, which was previously impossible. Moreover, SynthSeg+ enables scalable quality control of the produced results by automatic detection of faulty segmentations. Our tool is publicly available with FreeSurfer and can be used “out-of-the-box”, which facilitates its use and enhances reproducibility. By unlocking the analysis of heterogeneous clinical data, SynthSeg+ has the potential to transform neuroimaging studies, given the considerable abundance of clinical scans compared to the size of datasets used in research.