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Significance Long-acting antiretroviral drugs suppress viral replication in humanized mice. When administered CRISPR-mediated CCR5 and HIV-1LTR-Gag CRISPR editing the treatments resulted in the elimination of HIV-1 proviral DNA in lymphoid,… Click to show full abstract
Significance Long-acting antiretroviral drugs suppress viral replication in humanized mice. When administered CRISPR-mediated CCR5 and HIV-1LTR-Gag CRISPR editing the treatments resulted in the elimination of HIV-1 proviral DNA in lymphoid, bone marrow, and central nervous system tissues in 58% of the infected animals. Combinatorial CRISPR therapies proved statistically superior compared to single therapy for this HIV-1 cure strategy.
Keywords:
hiv;
crispr;
humanized mice;
crispr editing;
ccr5 hiv;
elimination
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!