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Significance During development, changes in chromatin structure regulate gene expression dynamics. A detailed understanding of gene regulatory networks will improve our understanding of organogenesis and disease mechanisms. Using single-nucleus RNA-sequencing… Click to show full abstract
Significance During development, changes in chromatin structure regulate gene expression dynamics. A detailed understanding of gene regulatory networks will improve our understanding of organogenesis and disease mechanisms. Using single-nucleus RNA-sequencing (snRNA-seq) and assay for transposase-accessible chromatin with sequencing (snATAC-seq), we comprehensively investigate the single-cell gene regulatory landscape during kidney organoid differentiation.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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