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Spatially explicit effective reproduction numbers from incidence and mobility data

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Significance The effective reproduction number quantifies the average number of secondary infections caused by an infected individual (within the population of their own resident community, or anywhere else) when the… Click to show full abstract

Significance The effective reproduction number quantifies the average number of secondary infections caused by an infected individual (within the population of their own resident community, or anywhere else) when the pool of susceptibles, the epidemiological conditions, and the related control measures may change in time. Estimates of the effective reproduction number from spatial data are essential in assessing public health policies and in communication about the state of an unfolding epidemic. Statistically robust estimates of reproduction numbers from surveillance data exist, quantifying temporal changes in disease transmission. However, what is missing to date is a set of space-explicit renewal equations that quantify infections imported to (and exported from) each community. Including spatial connections would imply a more accurate description of transmission mechanisms.

Keywords: effective reproduction; reproduction numbers; spatially explicit; explicit effective; numbers incidence; reproduction

Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023

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