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Significance Using combinatorial loss-of-function CRISPR screens, our study revealed a Bromo- and extra-terminal domain inhibitors (BETi) resistance network in KMT2A-r leukemia. Based on these findings, we have also revealed a… Click to show full abstract
Significance Using combinatorial loss-of-function CRISPR screens, our study revealed a Bromo- and extra-terminal domain inhibitors (BETi) resistance network in KMT2A-r leukemia. Based on these findings, we have also revealed a corresponding synergy treatment regimen, significantly improving strategies to prevent and treat BETi resistance and relapse that might be seen in the clinic.
Keywords:
inhibitor resistance;
crispr screens;
interrogating bromodomain;
resistance;
bromodomain inhibitor
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!