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Significance Antigen–immunoglobulin complexes are recognized by Fcγ receptors (FcγRs) coexpressed as activating and inhibitory (A/I) receptors on the same cells, in ratios that govern the outcome of immune responses. Antigen–immunoglobulin… Click to show full abstract
Significance Antigen–immunoglobulin complexes are recognized by Fcγ receptors (FcγRs) coexpressed as activating and inhibitory (A/I) receptors on the same cells, in ratios that govern the outcome of immune responses. Antigen–immunoglobulin complexes can also activate complement for recognition by complement receptors (CRs). Here, we find that protection with the same therapeutic antibody targeting Staphylococcus aureus is achieved in an FcγR-dependent manner in C57BL/6J mice and CR3-dependent manner in BALB/cJ mice. Protection was associated with the preferential expression of FcγRIV on C57BL/6J neutrophils and CR3 on BALB/cJ neutrophils. Thus, both the A/I FcγRs ratio and the relative abundance of FcγRs over CRs impact the effector activity of an antibody and the mechanism of elimination of immune complexes.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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