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Significance Solar is converted to chemical energy at thylakoid membranes of eukaryotic photosynthetic organisms, and proper lipid assembly in thylakoid membrane, particularly the transfer of lipid precursors from other organelles,… Click to show full abstract
Significance Solar is converted to chemical energy at thylakoid membranes of eukaryotic photosynthetic organisms, and proper lipid assembly in thylakoid membrane, particularly the transfer of lipid precursors from other organelles, is crucial. Sec14 homology proteins are identified in all eukaryotes, which can bind and transfer a wide range of lipids. By crystallizing the Sec14 domain of Arabidopsis Sec14 homology protein5 (AtSFH5) and relevant biochemical and genetic studies, we elucidated the specific binding modes of phosphatidic acid (PA) and unique structural features of plant Sec14 domains, and demonstrated the crucial roles of AtSFH5 and AtSFH7 in regulating chloroplast development providing a model for interorganelle phospholipid transport and a mechanism involving in the adaptive evolution of cellular plastids.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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