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Protein aggregate formed by alpha-synuclein is the hallmark of a series of neurodegenerative disorders known as synucleinopathies (also known as Lewy body diseases), including Parkinson’s disease (PD), dementia with Lewy… Click to show full abstract
Protein aggregate formed by alpha-synuclein is the hallmark of a series of neurodegenerative disorders known as synucleinopathies (also known as Lewy body diseases), including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA) (1). Globally PD alone affects the lives of more than 10 million people. In synucleinopathies, soluble, monomeric alpha-synuclein aggregates into fibrillar structures. The fibrillar alpha-synucleins, together with other protein aggregates, lipid
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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