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Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site

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Significance Bacterial division is an essential cellular process that involves the formation of a septum made of peptidoglycan. The septum is initially shared between daughters and must be processed to… Click to show full abstract

Significance Bacterial division is an essential cellular process that involves the formation of a septum made of peptidoglycan. The septum is initially shared between daughters and must be processed to complete division. Septal splitting has long been known to be mediated by enzymes called amidases that are controlled by an activator protein and the ABC-transporter-like complex called FtsEX. However, the mechanism of amidase regulation by this system has remained unclear. Here, we report the structure of FtsEX in complex with an amidase and amidase activator, revealing how ATP binding to the complex promotes amidase activation and providing structural information that may help target the activation mechanism for the development of cell lysis inducing antibiotics.

Keywords: ftsex; bacterial division; insights regulation; division; mechanistic insights

Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023

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