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Significance Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In… Click to show full abstract
Significance Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In the present study, we use a multi-scale surface scanning approach to enable a 3D architectural study of human primary cilia, the first in pancreatic islets and in any human tissue. Results provide a morphometric basis for understanding ciliary function including signaling capacity, axonemal motility, and cell-cell communication.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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