Significance The function and structure of the tryptophan-rich sensory proteins (TSPO) family have been the subject of contention. Here, we describe the finding of human mitochondrial TSPO1 as a cholesterol-dependent… Click to show full abstract
Significance The function and structure of the tryptophan-rich sensory proteins (TSPO) family have been the subject of contention. Here, we describe the finding of human mitochondrial TSPO1 as a cholesterol-dependent enzyme. This finding establishes the connections between cholesterol, protoporphyrin IX, oxygen, and TSPO1. This finding demonstrates the coevolution of TSPOs and their native lipid bilayer environment and provide a molecular basis for understanding the biochemical, cellular, physiological, and pathological roles of human TSPO1 and unify the structure and function of the TSPO family.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2025
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