Significance High-fat diet (HFD) causes the dysbiosis of the gut microbiota, which influences the host glucose metabolism and thus leads to type 2 diabetes (T2D). Determination of the microbial metabolism… Click to show full abstract
Significance High-fat diet (HFD) causes the dysbiosis of the gut microbiota, which influences the host glucose metabolism and thus leads to type 2 diabetes (T2D). Determination of the microbial metabolism pathway and certain agents contributing to T2D are pivotal for the therapeutic strategies. Here, we report that the HFD-induced gut microbiota dysbiosis of mice results in a depletion of 5-HIAA from disordered tryptophan metabolism involving the gut bacteria Burkholderia spp. and specific microbial enzymes. The results emphasize the value of 5-HIAA as a potential therapeutic agent since 5-HIAA can improve the glucose intolerance in vivo by promoting hepatic insulin signaling. More importantly, the decreased fecal levels of 5-HIAA might be considered as a premonitory diagnostic sign of T2D.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2024
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