Significance In cells, ZAP (zinc-finger antiviral protein) and KHNYN (KH-like and NYN domain containing protein) act together with partners to recognize and deplete viral RNA containing CpG dinucleotide clusters. Using… Click to show full abstract
Significance In cells, ZAP (zinc-finger antiviral protein) and KHNYN (KH-like and NYN domain containing protein) act together with partners to recognize and deplete viral RNA containing CpG dinucleotide clusters. Using purified recombinant proteins and biochemical assays, we define a minimal ZAP:KHNYN complex that degrades single-stranded RNA and propose a model for how this core would interact with viral RNA that contains CpG clusters.
Keywords:
zinc finger;
antiviral protein;
degrades single;
protein;
finger antiviral;
single stranded
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2024
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!