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ABSTRACT The 13C stable isotopic composition of 38 pharmaceutical products was investigated for six medicine analgesics classes ibuprofen, diclofenac, paracetamol, metamizole, ketoprofene, and combinations containing paracetamol to evaluate differences between… Click to show full abstract
ABSTRACT The 13C stable isotopic composition of 38 pharmaceutical products was investigated for six medicine analgesics classes ibuprofen, diclofenac, paracetamol, metamizole, ketoprofene, and combinations containing paracetamol to evaluate differences between manufacturers and production batches. Complementary measurements were performed by inductively coupled plasma-mass spectrometry. Linear discriminant analysis was applied on experimental obtained data set for differentiation of three investigated drug types. The carbon isotopic compositions were between −32.9 and −22.6‰. The lowest values of 13C (mean of −31.3‰) were obtained for metamizole from all six categories of investigated analgesics. The highest δ13C values were obtained for diclofenac (mean of −25.9‰). The most accurate elemental predictors were V, Al, Sb, As, Pb, and Mn.
Journal Title: Analytical Letters
Year Published: 2017
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