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Simple generalized reaction conditions for the conversion of primary aliphatic amines to surfactant-like guanidine salts with 1H-pyrazole carboxamidine hydrochloride

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ABSTRACT Improved reaction conditions for the electrophilic reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with,… Click to show full abstract

ABSTRACT Improved reaction conditions for the electrophilic reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with, were obtained in decent yields with short reaction times, minimal workup, and high level of purity. GRAPHICAL ABSTRACT

Keywords: surfactant like; guanidine salts; like guanidine; reaction conditions; reaction; pyrazole carboxamidine

Journal Title: Synthetic Communications
Year Published: 2017

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