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ABSTRACT Simple and efficient one-pot synthesis of 5-substituted isoxazoles and pyrazoles has been developed. The formation of the target isoxazoles and pyrazoles is initiated by 1,2-nucleophilic addition of generated in… Click to show full abstract
ABSTRACT Simple and efficient one-pot synthesis of 5-substituted isoxazoles and pyrazoles has been developed. The formation of the target isoxazoles and pyrazoles is initiated by 1,2-nucleophilic addition of generated in situ hydroxylamine or hydrazine to α-acetylenic γ-hydroxyaldehydes with further intramolecular cyclization of the adducts. The protocols are associated with readily available substrates, simple procedure, short reaction time, and moderate to high yields. GRAPHICAL ABSTRACT
Keywords:
isoxazoles pyrazoles;
intramolecular cyclization;
pot synthesis;
synthesis substituted;
substituted isoxazoles;
one pot
Journal Title: Synthetic Communications
Year Published: 2017
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Journal Title: Synthetic Communications
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!