ABSTRACT An eco-friendly, expeditious one-pot multicomponent synthesis of substituted 2-phenyl quinoxaline and 7-bromo-3-(4-ethylphenyl) pyrido[2,3-b]pyrazine 4a–k in water–ethanol from easily available starting materials as acetophenone 1, succinamide 2, aromatic amine 3,… Click to show full abstract
ABSTRACT An eco-friendly, expeditious one-pot multicomponent synthesis of substituted 2-phenyl quinoxaline and 7-bromo-3-(4-ethylphenyl) pyrido[2,3-b]pyrazine 4a–k in water–ethanol from easily available starting materials as acetophenone 1, succinamide 2, aromatic amine 3, in situ-generated α-iodo acetophenone from acetophenone, succinamide and catalyzed by silver iodide in combination with green solvent polyethylene glycol-400 and water (2:1) under microwave irradiation. The newly developed protocol with excellent yield of products in very short time of reaction by avoiding the use of lacrimatic α-chloro and α-bromocarbonyl compounds, volatile, toxic organic hazardous solvents, and reagents is the advantage of this research work. The final products were confirmed by their characterization data such as FTIR, 1H NMR, 13C NMR, Mass, HRMS and were compared with its reported method. GRAPHICAL ABSTRACT
Journal Title: Synthetic Communications
Year Published: 2017
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