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Cu2O/Cs2CO3/DMF: An efficient catalytic system for N-arylation of imidazole with aryl halides under ligand-free conditions

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ABSTRACT A ligand-free Cu-catalyzed protocol for the Ullmann-type N-arylation of N-containing heterocycles with aryl or heteroaryl iodides and bromides has been established. A broad range of functional groups is well… Click to show full abstract

ABSTRACT A ligand-free Cu-catalyzed protocol for the Ullmann-type N-arylation of N-containing heterocycles with aryl or heteroaryl iodides and bromides has been established. A broad range of functional groups is well tolerated on both of the cross-coupling partners, producing the desired products in good to excellent yields. GRAPHICAL ABSTRACT

Keywords: ligand free; dmf efficient; cs2co3 dmf; efficient catalytic; arylation; cu2o cs2co3

Journal Title: Synthetic Communications
Year Published: 2017

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