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Abstract An efficient and eco-friendly procedure for the synthesis of 2-amino-5-oxo-4-aryl-4H,5H-pyrano[3,2-c]chromene-3-carboxamide has been developed through a one-pot three-component condensation of 4-hydroxycoumarin with aldehydes and cyanoacetamide, in the presence of catalytic… Click to show full abstract
Abstract An efficient and eco-friendly procedure for the synthesis of 2-amino-5-oxo-4-aryl-4H,5H-pyrano[3,2-c]chromene-3-carboxamide has been developed through a one-pot three-component condensation of 4-hydroxycoumarin with aldehydes and cyanoacetamide, in the presence of catalytic amount of polystyrene-supported p-toluenesulfonic acid (PS-PTSA) as a highly active and reusable heterogeneous acid catalyst in EtOH at 80 °C conditions. This new procedure offers several advantages such as shorter reaction times, excellent yields, a wide range of functional group tolerance, easy experimental work-up procedure, operationally simple under metal-free reaction conditions and C-C/C-O bond formation. The catalyst can be recovered and reused for at least four runs without any significant impact on the product yields. GRAPHICAL ABSTRACT
Journal Title: Synthetic Communications
Year Published: 2018
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