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Abstract A concise synthesis of both enantiomers of γ-valerolactone has been developed from commercially available Alanine. The key steps in the synthesis of these γ-Lactones are DIBAL-H reduction of ester… Click to show full abstract
Abstract A concise synthesis of both enantiomers of γ-valerolactone has been developed from commercially available Alanine. The key steps in the synthesis of these γ-Lactones are DIBAL-H reduction of ester (9) followed by in situ Wittig reaction with EtO2CCH = PPh3 ylide (13) (Z/E = 1: 3.5) and one pot lactonization triggered by deprotection of O-TBS ether (14). Graphical Abstract
Keywords:
approach towards;
valerolactone alanine;
chiron approach;
towards optically;
pure valerolactone;
optically pure
Journal Title: Synthetic Communications
Year Published: 2018
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Journal Title: Synthetic Communications
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!