Abstract Here in, we described the synthesis of novel bisheterocycles imidazopyridine bearing xanthenedione by reacting various substituted 2-phenylimidazo [1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione in gluconic acid aqueous solution (GAAS) via a… Click to show full abstract
Abstract Here in, we described the synthesis of novel bisheterocycles imidazopyridine bearing xanthenedione by reacting various substituted 2-phenylimidazo [1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione in gluconic acid aqueous solution (GAAS) via a tandem Knoevenagel followed by Michael, cyclization & tautomerization sequence. The use of GAAS in organic synthesis offers significant benefits like cost-effective, simple operation, reusable catalyst and green method. The reaction completed in 2–12 h to afford white stable solid compounds with very good yield. The structures of the compounds are confirmed by analyzing MS, IR, 1H NMR and 13C NMR spectra. Further, the structure of compound 3 h was confirmed by XRD analysis. GRAPHICAL ABSTRACT
               
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