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Abstract A simple, and efficient synthesis of 2,2-difluoro-3H-benzothiophen-3-ol using readily available sodium chlorodifluoroacetate (SCDA) is reported. We also explore new chemistry of these difluoro compounds. The salient feature of this… Click to show full abstract
Abstract A simple, and efficient synthesis of 2,2-difluoro-3H-benzothiophen-3-ol using readily available sodium chlorodifluoroacetate (SCDA) is reported. We also explore new chemistry of these difluoro compounds. The salient feature of this approach includes operational simplicity and offers potential access to synthetically challenging building blocks for further elaboration. Functional group transformations of this new heterocycle are also presented. Graphical Abstract
Keywords:
difluoro benzothiophen;
benzothiophen via;
synthesis difluoro;
difluoro
Journal Title: Synthetic Communications
Year Published: 2019
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Journal Title: Synthetic Communications
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!