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Abstract Two novel structural isomers: the dihalo-5,5-dimethyl-2-cyclohexenones were synthesized. Regioselective Suzuki-Miyaura cross coupling reaction of the isomers with nine different aryl boronic acids afforded eighteen novel compounds: the 2-aryl-3-chloro-5,5-dimethyl-2-cyclohexenones and… Click to show full abstract
Abstract Two novel structural isomers: the dihalo-5,5-dimethyl-2-cyclohexenones were synthesized. Regioselective Suzuki-Miyaura cross coupling reaction of the isomers with nine different aryl boronic acids afforded eighteen novel compounds: the 2-aryl-3-chloro-5,5-dimethyl-2-cyclohexenones and the 3-aryl-2-chloro-5,5-dimethyl-2-cyclohexenones in 90–95% yields, which were characterized spectroscopically by IR, NMR and MS. The single crystal X-Ray diffraction ORTEP views of four representative compounds unambiguously confirm the formation of substituted cyclohexenones. Graphical Abstract
Journal Title: Synthetic Communications
Year Published: 2020
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