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Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst

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Abstract Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1… Click to show full abstract

Abstract Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1 is easily available, cheap, and eco benign. Graphical Abstract

Keywords: multicomponent synthesis; thiamine hydrochloride; functionalized tetrahydropyridines; synthesis highly; highly functionalized

Journal Title: Synthetic Communications
Year Published: 2020

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