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Hantzsch synthesis of bis(1,4-dihydropyridines) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridines) linked to pyrazole units as novel hybrid molecules

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Abstract A novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine) derivatives which are linked to pyrazole units were prepared via Hantzsch like reaction of the bis-aldehydes with the respective 3-aminocrotonitrile and pyrazolone… Click to show full abstract

Abstract A novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine) derivatives which are linked to pyrazole units were prepared via Hantzsch like reaction of the bis-aldehydes with the respective 3-aminocrotonitrile and pyrazolone derivatives. Graphical Abstract

Keywords: linked pyrazole; hantzsch synthesis; pyrazole units; synthesis bis; bis; bis tetrahydrodipyrazolo

Journal Title: Synthetic Communications
Year Published: 2020

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