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Abstract An efficient asymmetric oxidation of sulfides was achieved using (R)-6,6'-dibromo-BINOL as chiral ligand in combination with Ti(OiPr)4 using 70% aqueous tertiary butyl hydroperoxide as oxidant. The resulting sulfoxides had… Click to show full abstract
Abstract An efficient asymmetric oxidation of sulfides was achieved using (R)-6,6'-dibromo-BINOL as chiral ligand in combination with Ti(OiPr)4 using 70% aqueous tertiary butyl hydroperoxide as oxidant. The resulting sulfoxides had high enantiopurities and good yields. A range of aryl alkyl and aryl benzyl sulfides were oxidized to the corresponding sulfoxides with 78–95% ee in 72–80% yields. Graphical Abstract
Keywords:
oxidation sulfides;
asymmetric oxidation;
sulfides catalyzed;
dibromo binol
Journal Title: Synthetic Communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Synthetic Communications
Year Published: 2020
Link to full text (if available)
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recommendations!