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Imidazolium ylide mediated tandem Knoevenagel–Michael–O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans

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Abstract The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of Et3N. Graphical… Click to show full abstract

Abstract The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of Et3N. Graphical Abstract

Keywords: mediated tandem; michael cyclization; tandem knoevenagel; imidazolium ylide; ylide mediated; knoevenagel michael

Journal Title: Synthetic Communications
Year Published: 2020

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