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Abstract The efficient synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks has been developed. The synthesis used classic reactions from readily available starting… Click to show full abstract
Abstract The efficient synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks has been developed. The synthesis used classic reactions from readily available starting materials. Reactions of the lactone bearing an oxo-containing α-tetrasubstituted center with MeOH and cephalotaxine, respectively, proceeded smoothly to give the corresponding ring-opening products in 80% and 65% yield. Graphical Abstract
Keywords:
side chains;
chains homoharringtonine;
ester side;
harringtonine using;
synthesis ester;
homoharringtonine harringtonine
Journal Title: Synthetic Communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Synthetic Communications
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!