LAUSR

Abstract Heterocycles constitute a very important class of compounds in organic chemistry. The heterocyclic frameworks represent the main structural subunits of various natural products and biologically active compounds. The formation of higher-membered heterocyclic compounds has been a center of focus for a very long time and has attracted great attention for the development of improved synthetic approaches toward milder, clean, and high yielding strategies. Several classical approaches involve carbon-heteroatom bond-forming reactions like dipolar cycloaddition for ring closure, reductive amination, or nucleophilic substitution in the synthesis of these compounds. This review article is focused on the synthesis of several higher-membered heterocyclic compounds. Graphical Abstract