LAUSR

Abstract Eucalyptol or 1,8-cineole, a bio-based monoterpene, whose potential has been explored as a viable alternative reaction media for the development of several heterocyclic systems. As an eco-benign solvent eucalyptol has been found to be a promising, bio-competent, green media in our protocols without allowing the involvement of any transition metal catalyst at suitable temperature. In our present work, we carried out the synthesis of 2,3-dihydroquinazolin-4(1H)-one and isoxazolone derivatives from several aldehydes by using this unexplored but effective eco-benign solvent. The use of this recyclable solvent helped us to avoid the use of hazardous, toxic, and harsh reaction conditions toward the synthesis of different desired heterocyclic systems. Graphical Abstract