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Abstract Synthesis of spirooxindole derivatives was achieved by combining Knoevenagel condensation and Michael addition between isatin, malononitrile, and dimedone or cyclohexan-1,3-dione in presence of ammonium acetate by simple stirring in… Click to show full abstract
Abstract Synthesis of spirooxindole derivatives was achieved by combining Knoevenagel condensation and Michael addition between isatin, malononitrile, and dimedone or cyclohexan-1,3-dione in presence of ammonium acetate by simple stirring in ethanol at room temperature. Spirooxindole derivatives possess promising biological activities like antitumor, antifungal, antimalarial, and anti-HIV. The analytically pure spirooxindoles formed in a concise reaction time without recrystallization or column chromatography. This method is safe and avoids the use of toxic chemicals and excess consumption of energy. Graphical Abstract
Journal Title: Synthetic Communications
Year Published: 2023
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