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ABSTRACT Toward the development of drug carriers that are capable of crossing biological membranes, controlled emulsion polymerization has been utilized to produce nanoparticulate carriers from the combination of poly(alkyl cyanoacrylate)… Click to show full abstract
ABSTRACT Toward the development of drug carriers that are capable of crossing biological membranes, controlled emulsion polymerization has been utilized to produce nanoparticulate carriers from the combination of poly(alkyl cyanoacrylate) and alkylglyceryl dextran to a molecular structure designed to combine the nonimmunogenic and stabilizing properties of dextran with the demonstrated permeation enhancing ability of alkylglycerols. To this aim, a systematic series of alkylglyceryl dextrans have been synthesized and functionalized with ethyl or butyl cyanoacrylates to form stable polymeric nanocarriers (100–500 nm). Results of investigations into their capability to act as controlled-release devices and their cytotoxicity against bEnd3 cells are reported. GRAPHICAL ABSTRACT
Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2017
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