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ABSTRACT The esterification reaction between curdlan and maleic anhydride was performed to provide polymerizable double bonds and pH-sensitive carboxylic groups for the curdlan chains. The new derivative was used as… Click to show full abstract
ABSTRACT The esterification reaction between curdlan and maleic anhydride was performed to provide polymerizable double bonds and pH-sensitive carboxylic groups for the curdlan chains. The new derivative was used as macromolecular cross-linker in the polymerization of N-isopropylacrylamide, when thermo and pH-sensitive networks were obtained in the form of microparticles. The loading and releasing profiles of a model macromolecular drug, lysozyme, were evaluated. The protein release rate was influenced by the pH and temperature. The pulsatile release of the lysozyme was also observed, the pulse being the swelling of the microparticles due to the decrease of the temperature under the volume phase transition temperature. GRAPHICAL ABSTRACT
Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2018
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