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ABSTRACT We fabricated two β-tricalcium phosphates (β-TCP) microsphere-hyaluronic acid composites and evaluate their efficacy as recombinant human bone morphogenetic protein-2 (rhBMP-2) carriers when combined with titanium implants in rabbit tibial… Click to show full abstract
ABSTRACT We fabricated two β-tricalcium phosphates (β-TCP) microsphere-hyaluronic acid composites and evaluate their efficacy as recombinant human bone morphogenetic protein-2 (rhBMP-2) carriers when combined with titanium implants in rabbit tibial diaphysis. After 4 weeks, the new bone formation was observed with plain radiographs and histology and was analyzed via micro-CT. Micro-CT analyses results showed the composites with hydrogel and BMP had a significantly higher bone to implant contact ratios and new bone formation than the other groups did. Our results indicated that rhBMP-2 loaded β-TCP/hydrogel composites could significantly elevate osteogenesis and osseointegration of the titanium implants in rabbit tibia medullary space. GRAPHICAL ABSTRACT
Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2019
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