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Abstract In an effort to reduce the dose of drugs and in order to improve drug efficacy, avermectin (AVM) was encapsulated by amphipathic polyacrylic ester (PAE) via self-assembly. The experimental… Click to show full abstract
Abstract In an effort to reduce the dose of drugs and in order to improve drug efficacy, avermectin (AVM) was encapsulated by amphipathic polyacrylic ester (PAE) via self-assembly. The experimental results indicated that the AVM/PAE nanoparticles were spherical in shape, homogeneous dispersion, and had a core-shell structure, the particle size ranged from 172.7 nm to 337.8 nm, the highest encapsulation efficiency and loading capacity were 62.11 and 25.65%. The anti-UV property has been significantly improved. Consistent with the Korsmeyer–Peppas model, the release rate was observed to be higher upon decreasing Tg and increasing the core-shell ratio. Graphical Abstract
Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2019
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