Photo by sxy_selia from unsplash
Abstract In this work, the phytochemical anticancer thymoquinone (TQ) and near-infrared plasmonic gold nanorods (AuNRs) were loaded in folate-targeted pegylated poly(d, l-lactide-co-glycolide) (PLGA-PEG-FA) nanocapsules. This polymeric regime exhibited in vitro… Click to show full abstract
Abstract In this work, the phytochemical anticancer thymoquinone (TQ) and near-infrared plasmonic gold nanorods (AuNRs) were loaded in folate-targeted pegylated poly(d, l-lactide-co-glycolide) (PLGA-PEG-FA) nanocapsules. This polymeric regime exhibited in vitro sustained release kinetics of both TQ and AuNRs. MTT assay showed the strong and synergistic chemo-photothermal effects on SCC-15 cells incubated with the combination therapy associated with dramatic ultrastructural changes on the morphology of the cells. The enhanced anticancer efficacy, as indicated by tumor regression and histopathological examinations, proved the ability of the proposed regime to achieve strong synergistic anticancer effects and selective tumor targeting via dual-modal targeted system. Graphical Abstract
Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!