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In vitro cytotoxicity and hyperthermia studies of superparamagnetic poly(urea-urethane) nanoparticles obtained by miniemulsion polymerization in human erythrocytes and NIH3T3 and HeLa cells

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Abstract In this work, magnetic nanoparticles were encapsulated in PUU by miniemulsion polymerization resulting in particles with an average diameter of 164 nm and superparamagnetic proprieties. The hemocompatibility was confirmed by… Click to show full abstract

Abstract In this work, magnetic nanoparticles were encapsulated in PUU by miniemulsion polymerization resulting in particles with an average diameter of 164 nm and superparamagnetic proprieties. The hemocompatibility was confirmed by hemolysis and flow cytometry analyses. When an AC magnetic field was applied under superparamagnetic PUU nanoparticles the temperature reached the threshold temperature required for cancer hyperthermia, decreasing the HeLa cells viability at all concentrations tested. On the other hand, when the NIH3T3 cells were submitted to hyperthermia no cytotoxic effect was observed. In particular, the hyperthermia assay proved to be effective in destroying cancer cells while preserving non-tumor ones. Graphical Abstract

Keywords: miniemulsion polymerization; vitro cytotoxicity; hela cells; hyperthermia

Journal Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Year Published: 2020

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